Universal Cells Inc.

Technology | Universal Cells

Our Technology | Recombinant Adeno-Associated Virus | Editing the genome without breaking it | rAAV cassette | No Off-target Cutting | No On Target Mistakes | Non-toxic Delivery | No Nuclease Proteins | Pluripotent Stem Cells (PSCs) | Cells for every organ | Universal Donor Cells | OUR GOAL One cell for everyone No immune suppression. No donor matching. No rejection. | HLA Engineering | Total Control of Antigen Presentation | HLA Class I | HLA class II engineering | Selected Publications | Russell, D.W., and Hirata, R.K. (1998). Human gene targeting by viral vectors. Nature Genetics 18, 325-330. | Rutledge, E.A., Halbert, C.L., and Russell, D.W. (1998). Infectious clones and vectors derived from adeno-associated virus (AAV) serotypes other than AAV type 2. Journal of Virology 72, 309-319. | Thomson, J.A., Itskovitz-Eldor, J., Shapiro, S.S., Waknitz, M.A., Swiergiel, J.J., Marshall, V.S., and Jones, J.M. (1998). Embryonic stem cell lines derived from human blastocysts. Science 282, 1145-1147. | Inoue, N., Hirata, R.K., and Russell, D.W. (1999). High-fidelity correction of mutations at multiple chromosomal positions by adeno-associated virus vectors. Journal of Virology 73, 7376-7380. | Inoue, N., Dong, R., Hirata, R.K., and Russell, D.W. (2001). Introduction of single base substitutions at homologous chromosomal sequences by adeno-associated virus vectors. Mol Ther. 3, 526-530. | Hirata, R., Chamberlain, J., Dong, R., and Russell, D.W. (2002). Targeted transgene insertion into human chromosomes by adeno-associated virus vectors. Nat Biotechnol 20, 735-738. | Chamberlain, J.R., Schwarze, U., Wang, P., Hirata, R.K., Hankenson, K.D., Pace, J.M., Underwood, R.A., Song, K.M., Sussman, M., Byers, P.H., et al. (2004). Gene targeting in stem cells from individuals with osteogenesis imperfecta. Mol Ther. 2008 Jan; 16(1): 187–193. | Takahashi, K., Tanabe, K., Ohnuki, M., Narita, M., Ichisaka, T., Tomoda, K., and Yamanaka, S. (2007). Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 131, 861-872. | Yu, J., Vodyanik, M.A., Smuga-Otto, K., Antosiewicz-Bourget, J., Frane, J.L., Tian, S., Nie, J., Jonsdottir, G.A., Ruotti, V., Stewart, R., et al. (2007). Induced pluripotent stem cell lines derived from human somatic cells. Science 318, 1917-1920. | Mitsui, K., Suzuki, K., Aizawa, E., Kawase, E., Suemori, H., Nakatsuji, N., and Mitani, K. (2009). Gene targeting in human pluripotent stem cells with adeno-associated virus vectors. Biochem Biophys Res Commun 388, 711-717. | Khan, I.F., Hirata, R.K., Wang, P.R., Li, Y., Kho, J., Nelson, A., Huo, Y., Zavaljevski, M., Ware, C., and Russell, D.W. (2010). Engineering of human pluripotent stem cells by AAV-mediated gene targeting. Mol Ther 18, 1192-1199. | Deyle, D.R., Khan, I.F., Ren, G., Wang, P.R., Kho, J., Schwarze, U., and Russell, D.W. (2012). Normal Collagen and Bone Production by Gene-targeted Human Osteogenesis Imperfecta iPSCs. Mol Ther 20, 204-213. | Li, L.B., Chang, K.H., Wang, P.R., Hirata, R.K., Papayannopoulou, T., and Russell, D.W. (2012). Trisomy correction in Down syndrome induced pluripotent stem cells. Cell Stem Cell 11, 615-619. | Riolobos, L., Hirata, R.K., Turtle, C.J., Wang, P.R., Gornalusse, G.G., Zavajlevski, M., Riddell, S.R., and Russell, D.W. (2013). HLA engineering of human pluripotent stem cells. Mol Ther 21, 1232-1241. | Deyle, D.R., Hansen, R.S., Cornea, A.M., Li, L.B., Burt, A.A., Alexander, I.E., Sandstrom, R.S., Stamatoyannopoulos, J.A., Wei, C.L., and Russell, D.W. (2014). A genome-wide map of adeno-associated virus-mediated human gene targeting. Nat Struct Mol Biol 21, 969-975. | Gornalusse, G.G., Hirata, R.K., Funk, S.E., Riolobos, L., Lopes, V.S., Manske, G., Prunkard, D., Colunga, A.G., Hanafi, L.A., Clegg, D.O., et al. (2017). HLA-E-expressing pluripotent stem cells escape allogeneic responses and lysis by NK cells. Nat Biotechnol 35, 765-772.